Chapters Transcript Video How should clinicians monitor brensocatib once a patient has been committed to this treatment? CLICK HERE FOR CME CREDIT Back to Symposium There are several aspects of forensic ade that are particularly attractive, uh. One, is that there are no major contraindications. Uh, just about any other disease, uh, would not be, uh, a contraindication to prescribing the drug. The second is it has no major drug-drug interactions. Uh, that, that's almost semi, uh, miraculous. And the third is that even though the neutrophils uh express uh uh lower levels of the proteolytic enzymes, patients are not immune suppressed or immune compromised. The, the side effects are, uh, generally mild, uh, and, uh, infrequent. The few patients that I have seen who have been on the drug, uh, for the last 2 or 3 months are showing, uh, diminished cough, uh, decreased sputum production. Uh, less fatigue, uh, all of the most bothersome symptoms with bronchiectasis. Now, uh, that is not, uh, a scientific survey, uh, but, uh, there are a lot of centers that are collecting data on their patients with bronchiectasis. And I, I think you will see, uh, within the next, uh, easily within the next 6 months. Uh, papers from individual centers, uh, evaluating, uh, the clinical response, the symptomatic response. Uh, it, it's kind of tough to evaluate a drug on what you don't see. So, uh, a patient may have fewer exacerbations in a year, but you'd have to wait a year from the time you started the drug to know that. Um, but I'm looking to the, uh, the next. Uh, the next few publications on the studies to give us more granular information, uh, about the, uh, about the drug. Uh, in terms of side effects, the, the one thing that most patients, uh, find, uh, very appealing is that it, it has no GI side effects. Uh, unlike almost every other drug we use in this business, uh, it doesn't cause nausea or vomiting or loss of appetite. Uh, most of the side effects are mild and reversible, uh, with discontinuation of the drug, and it's always important to remind people there are no, uh, fatal side effects associated with Brins Academy. Created by Presenter Professor David E. Griffith, MD Professor of MedicineNational Jewish HealthDenver, Colorado, USA
