About Bronchiectasis (NCFBE) Pulmonary Medicine Intelligence Zone
Program Medium
Internet-based program
Method of Physician Participation Utilized in Learning Process
There are no fees for participating and receiving CME credit for this activity. During the period February 2, 2026 to February 2, 2028, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view the activity, totaling 3.0 hours, to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out CME certificate.
Estimated Time to Complete Educational Activity
3.0 hours. Physicians must study the enduring activity, and are expected to view every segment to successfully complete the activity and earn CME credit.
Course Overview
In this web-based program, physicians will learn how recent developments in novel targets and treatments have advanced the management of non-cystic fibrosis bronchiectasis (NCFBE)
Release Date
February 2, 2026
Expiration Date
February 2, 2028
Intended Audience
This complimentary CME educational activity is designed for all healthcare providers (HCPs) involved in developing, delivering, consulting, and monitoring care for patients with NCFBE, including pulmonary medicine and infectious disease specialists, and related clinicians.
Registration
Participation in this activity is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.
Grantor Support
This activity is supported by an independent medical education grant from Insmed.
Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Massachusetts Chan Medical School and CMEducation Resources, LLC. The University of Massachusetts Chan Medical School is accredited by the ACCME to provide continuing medical education for physicians.
Credit Designation Statement
The University of Massachusetts Chan Medical School, Office of Continuing Medical Education designates this enduring material for a maximum of 3.0 AMA PRA Category 1 Credits(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Policy on Faculty & Provider Disclosure
It is the policy of the University of Massachusetts Chan Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Chan Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.
Program Faculty and Disclosure
Professor James Chalmers
Professor (Clinical), Molecular and Clinical Medicine
School of Medicine
University of Dundee School of Medicine
Dundee, Scotland, United Kingdom
Research grants or consulting fees: Astrazeneca, Boehringer Ingelheim, Chiesi, Gilead Sciences, Grifols, Insmed, Janssen, Novartis, Zambon
Prof. Francesco Blasi, MD, FERS
Professor of Respiratory Medicine
Department of Pathophysiology and Transplantation,
Vice Rector for Relations with the National Health Service
University of Milan
Dean of the School of Medicine, University of Milan
Milan, Italy
Grants, Speaker Fees and Conferences: AstrraZeneca, Chiesi, Gilead, GSK, Grifols, Guidotti-Malesci, Insmed, Menari, Novartis, Pfizer, Sanofi, Viatris, Vertex and Zambon
Consulting: AstraZeneca, Chiesi, GSK, Manri
Professor David E. Griffith, MD
Professor of Medicine
National Jewish Health
Denver, Colorado, USA
Consultant, Contracted Research and Speaker: Insmed
Professor Michael Loebinger, MA, FRCP, PhD
Director of the Lung Division, Clinical Director of Laboratory Medicine, Deputy Medical Director, Consultant Respiratory Medicine,
Royal Brompton & Harefield Hospitals
Professor of Practice (Respiratory Medicine),
National Heart and Lung Institute
Imperial College London
London, United Kingdom
Received consultancy and/or lecture fees from Insmed, Grifols, AstraZeneca, Armata, and Chiesi over past 3 years
Anne E. O’Donnell MD
The Nehemiah and Naomi Cohen Chair in Pulmonary Disease Research
Professor of Medicine
Interim Chair, Department of Medicine
Chief, Division of Pulmonary, Critical Care and Sleep Medicine
Georgetown University Medical Center/Medstar Georgetown University Hospital
Washington, DC, USA
Consultant: Electromed, Insmed, Merck, Astra Zeneca
Principal Investigator (Georgetown University):Insmed, Zambon, Johnson and Johnson, Paratek, Redhill
Professor Kevin Winthrop, MD, MPH
Professor of Infectious Diseases, Ophthalmology,
Professor of Public Health and Preventive Medicine (joint appointment),
Division of Infectious Diseases, OHSU
Oregon Health and Sciences University
Portland, Oregon, USA
Research funding from NIH, PCORI, Insmed
Scientific consultant work for Bayer, Insmed
Data safety monitoring boards for RCTs conducted by UCB, Roche, Astellas, Lilly, Janssen, Galapagos, Gilead
Program Managers and Web Editor Disclosure
Program Managers Gideon Bosker, MD and Denise Leary have nothing to disclose.
Educational Objectives
Upon completion of this activity, participants will be able to:
- Discuss the epidemiology, unmet therapeutic needs, global demographics, and disease burden for NCFBE based on regional and global prevalence, susceptible populations, and strategies for early confirmation of the diagnosis of NCFBE
- Outline the risk factors, early clinical clues, and clinical presentation of NCFBE in a wide range of patient with predisposing risk factors
- Review and apply International Guidelines—ERS, ATS, ARA, BTS, etc.—for managing NCFBE lung disease
- Implement patient-centric, self-care measures that ensure recognition of disease exacerbation and that improve regimen adherence and completion of treatments deployed for NCBE
- Describe the pathobiology of NCFBE, especially the role of neutrophils as cellular triggers and maintenance of pathoinflammatory changes and pathways that are responsible for progressive lung tissue destruction and that predispose to recurrent exacerbations of NCFBE
- Explain the mechanistic role of neutrophil serine proteases (NSPs) as mediators of inflammation in NCFBE and the associated role of inhibition of DPP-1 to mitigate neutrophil-mediated patho-inflammatory changes that are responsible for progressive lung tissue destruction and acute changes that predispose to exacerbations of NCFBE;
- Outline the role, design, implications and potential translational applications of landmark clinical trials evaluating the safety, efficacy, dosing, and clinical outcomes in patients with NCFBE who have been treated with novel, investigational agents targeting DPP-1 as a primary mechanism for reducing activity levels of NSPs and mitigating other patho-inflammatory changes mediated by neutrophils in the setting of NCFBE
Hardware and Software Requirements:
To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.
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Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.
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